The current Mercedes-Benz CLS covers up to 1,200 km on a full tank, based on combined-cycle consumption. Figures below are the best-range variant in each generation.
| Years | Powertrain | Range |
|---|---|---|
| 2004–2010 | Combustion | 1,053 |
| 2010–2014 | Combustion | 1,333 |
| 2014–2018 | Combustion | 1,283 |
| 2018–2021 | Combustion | 1,269 |
| 2021–present | Combustion | 1,200 |
Range is calculated from each variant’s fuel tank capacity and combined-cycle consumption (tank ÷ consumption × 100), for the best-range variant in each generation — real-world range varies with driving style and conditions. Figures outside a plausible range for the tank size are excluded.