The Mercedes-Benz S-Class W222 (2013-2017) was offered with 12 distinct engine configurations across its trim range.
| Engine | Power | Torque | Transmission | Drive | Top speed | 0-100 km/h | Consumption | Available on |
|---|---|---|---|---|---|---|---|---|
| 6.0L Petrol | 630 hp | 1,000 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.3 s | 11.9 l/100km | 1 trim |
| 5.5L Petrol | 585 hp | 900 Nm | Automatic | All Wheel Drive | 250 km/h | 4.0 s | 10.3 l/100km | 1 trim |
| 5.5L Petrol | 585 hp | 900 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.4 s | 10.1 l/100km | 1 trim |
| 6.0L Petrol | 530 hp | 830 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.0 s | 11.7 l/100km | 2 trims |
| 4.7L Petrol | 456 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 5.0 s | 9.4 l/100km | 13 trims |
| 4.7L Petrol | 456 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.0 s | 8.9 l/100km | 13 trims |
| 3.0L Petrol | 333 hp | 480 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.2 s | 2.8 l/100km | 3 trims |
| 3.0L Petrol | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 6.1 s | 8.4 l/100km | 6 trims |
| 3.5L Petrol | 306 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.8 s | 6.0 l/100km | 6 trims |
| 3.0L Diesel | 258 hp | 620 Nm | Automatic | All Wheel Drive | 250 km/h | 6.8 s | 5.7 l/100km | 12 trims |
| 3.0L Diesel | 258 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.5 s | 5.4 l/100km | 12 trims |
| 2.1L Diesel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 240 km/h | 7.6 s | 4.3 l/100km | 12 trims |
Each row is a distinct mechanical configuration — engine size, power output, transmission, drivetrain and fuel type — deduplicated across equipment trims that share the same engine. Trim-only differences (interior, wheels, options) do not create a separate row.