The Mercedes-Benz S-Class W223 (2020-2026) was offered with 14 distinct engine configurations across its trim range.
| Engine | Power | Torque | Transmission | Drive | Top speed | 0-100 km/h | Consumption | Available on |
|---|---|---|---|---|---|---|---|---|
| 4.0L Petrol | 612 hp | 900 Nm | Automatic | Rear Wheel Drive | 290 km/h | 3.3 s | 4.6 l/100km | 1 trim |
| 4.0L Petrol | 503 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 4.4 s | 10.1 l/100km | 2 trims |
| 3.0L Petrol | 449 hp | 560 Nm | Automatic | All Wheel Drive | 250 km/h | 4.7 s | 8.1 l/100km | 2 trims |
| 3.0L Petrol | 435 hp | 520 Nm | Automatic | All Wheel Drive | 250 km/h | 4.9 s | 7.8 l/100km | 2 trims |
| 3.0L Petrol | 381 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 5.0 s | 8.4 l/100km | 2 trims |
| 3.0L Diesel | 367 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 5.0 s | 6.3 l/100km | 2 trims |
| 3.0L Petrol | 367 hp | 500 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.9 s | 0.7 l/100km | 5 trims |
| 3.0L Petrol | 367 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 4.9 s | 0.7 l/100km | 3 trims |
| 2.9L Diesel | 330 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 5.4 s | 6.4 l/100km | 2 trims |
| 3.0L Diesel | 313 hp | 650 Nm | Automatic | All Wheel Drive | 250 km/h | 5.5 s | 6.3 l/100km | 1 trim |
| 3.0L Diesel | 313 hp | 650 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.6 s | 6.1 l/100km | 2 trims |
| 3.0L Petrol | 299 hp | 450 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.9 s | 0.6 l/100km | 2 trims |
| 2.9L Diesel | 286 hp | 600 Nm | Automatic | All Wheel Drive | 250 km/h | 6.2 s | 6.3 l/100km | 3 trims |
| 2.9L Diesel | 286 hp | 600 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.4 s | 6.2 l/100km | 2 trims |
Each row is a distinct mechanical configuration — engine size, power output, transmission, drivetrain and fuel type — deduplicated across equipment trims that share the same engine. Trim-only differences (interior, wheels, options) do not create a separate row.