The Mercedes-Benz S-Class W221 (2005-2009) was offered with 12 distinct engine configurations across its trim range.
| Engine | Power | Torque | Transmission | Drive | Top speed | 0-100 km/h | Consumption | Available on |
|---|---|---|---|---|---|---|---|---|
| 6.0L Petrol | 612 hp | 999 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.4 s | 14.8 l/100km | 1 trim |
| 6.2L Petrol | 525 hp | 630 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.6 s | 14.8 l/100km | 2 trims |
| 5.5L Petrol | 517 hp | 830 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.6 s | 14.3 l/100km | 1 trim |
| 5.5L Petrol | 388 hp | 530 Nm | Automatic | All Wheel Drive | 250 km/h | 5.4 s | 12.2 l/100km | 4 trims |
| 5.5L Petrol | 388 hp | 530 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.4 s | 11.8 l/100km | 4 trims |
| 4.7L Petrol | 340 hp | 460 Nm | Automatic | All Wheel Drive | 250 km/h | 5.9 s | 11.7 l/100km | 4 trims |
| 4.7L Petrol | 340 hp | 460 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.9 s | 11.3 l/100km | 4 trims |
| 4.0L Diesel | 320 hp | 730 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.0 s | 9.6 l/100km | 4 trims |
| 3.5L Petrol | 272 hp | 350 Nm | Automatic | All Wheel Drive | 250 km/h | 7.3 s | 10.7 l/100km | 6 trims |
| 3.5L Petrol | 272 hp | 350 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.3 s | 10.1 l/100km | 6 trims |
| 3.0L Diesel | 235 hp | 540 Nm | Automatic | All Wheel Drive | 245 km/h | 7.8 s | 8.9 l/100km | 6 trims |
| 3.0L Diesel | 235 hp | 540 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.5 s | 7.7 l/100km | 12 trims |
Each row is a distinct mechanical configuration — engine size, power output, transmission, drivetrain and fuel type — deduplicated across equipment trims that share the same engine. Trim-only differences (interior, wheels, options) do not create a separate row.