El Mercedes-Benz C-Class Facelift 2004 (2004-2007) se ofreció con 28 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 5.4L Gasolina | 367 hp | 510 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.2 s | 11.9 l/100km | 1 acabado |
| 3.5L Gasolina | 272 hp | 350 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.9 s | 10.3 l/100km | 6 acabados |
| 3.5L Gasolina | 272 hp | 350 Nm | Manual | Rear Wheel Drive | 250 km/h | 6.4 s | 9.5 l/100km | 3 acabados |
| 3.0L Diésel | 231 hp | 540 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.8 s | 7.6 l/100km | 1 acabado |
| 3.0L Gasolina | 231 hp | 300 Nm | Automatic | All Wheel Drive | 247 km/h | 7.6 s | 9.8 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.2 s | 9.4 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Manual | Rear Wheel Drive | 250 km/h | 7.3 s | 9.4 l/100km | 3 acabados |
| 3.0L Diésel | 224 hp | 510 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.2 s | 7.3 l/100km | 3 acabados |
| 3.0L Diésel | 224 hp | 415 Nm | Manual | Rear Wheel Drive | 246 km/h | 8.1 s | 6.9 l/100km | 3 acabados |
| 3.2L Gasolina | 218 hp | 310 Nm | Automatic | Rear Wheel Drive | 245 km/h | 8.0 s | 10.7 l/100km | 6 acabados |
| 3.2L Gasolina | 218 hp | 310 Nm | Manual | Rear Wheel Drive | 248 km/h | 7.7 s | 10.9 l/100km | 3 acabados |
| 2.5L Gasolina | 204 hp | 245 Nm | Automatic | Rear Wheel Drive | 238 km/h | 8.9 s | 9.3 l/100km | 3 acabados |
| 2.5L Gasolina | 204 hp | 245 Nm | Manual | Rear Wheel Drive | 245 km/h | 8.4 s | 9.3 l/100km | 3 acabados |
| 1.8L Gasolina | 192 hp | 260 Nm | Automatic | Rear Wheel Drive | 236 km/h | 8.2 s | 8.9 l/100km | 3 acabados |
| 1.8L Gasolina | 192 hp | 260 Nm | Manual | Rear Wheel Drive | 240 km/h | 8.1 s | 8.9 l/100km | 3 acabados |
| 2.7L Diésel | 170 hp | 400 Nm | Automatic | Rear Wheel Drive | 225 km/h | 9.1 s | 7.1 l/100km | 3 acabados |
| 2.7L Diésel | 170 hp | 400 Nm | Manual | Rear Wheel Drive | 230 km/h | 8.9 s | 6.8 l/100km | 3 acabados |
| 2.6L Gasolina | 170 hp | 240 Nm | Automatic | All Wheel Drive | 232 km/h | 10.0 s | 10.6 l/100km | 3 acabados |
| 2.6L Gasolina | 170 hp | 240 Nm | Automatic | Rear Wheel Drive | 232 km/h | 9.5 s | 10.2 l/100km | 3 acabados |
| 2.6L Gasolina | 170 hp | 240 Nm | Manual | Rear Wheel Drive | 235 km/h | 9.2 s | 10.7 l/100km | 3 acabados |
| 1.8L Gasolina | 163 hp | 240 Nm | Automatic | Rear Wheel Drive | 231 km/h | 9.3 s | 8.5 l/100km | 3 acabados |
| 1.8L Gasolina | 163 hp | 240 Nm | Manual | Rear Wheel Drive | 234 km/h | 9.3 s | 8.4 l/100km | 3 acabados |
| 2.1L Diésel | 150 hp | 340 Nm | Automatic | Rear Wheel Drive | 218 km/h | 10.3 s | 6.8 l/100km | 6 acabados |
| 2.1L Diésel | 150 hp | 340 Nm | Manual | Rear Wheel Drive | 224 km/h | 10.1 s | 6.4 l/100km | 6 acabados |
| 1.8L Gasolina | 143 hp | 220 Nm | Automatic | Rear Wheel Drive | 220 km/h | 9.9 s | 8.2 l/100km | 3 acabados |
| 1.8L Gasolina | 143 hp | 220 Nm | Manual | Rear Wheel Drive | 223 km/h | 9.7 s | 7.9 l/100km | 3 acabados |
| 2.1L Diésel | 122 hp | 270 Nm | Automatic | Rear Wheel Drive | 203 km/h | 11.9 s | 6.9 l/100km | 6 acabados |
| 2.1L Diésel | 122 hp | 270 Nm | Manual | Rear Wheel Drive | 208 km/h | 11.7 s | 6.3 l/100km | 6 acabados |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.