El Mercedes-Benz C-Class Facelift 2018 (2018-2021) se ofreció con 25 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 4.0L Gasolina | 510 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.0 s | 9.9 l/100km | 1 acabado |
| 4.0L Gasolina | 476 hp | 650 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.1 s | 9.9 l/100km | 1 acabado |
| 3.0L Gasolina | 390 hp | 520 Nm | Automatic | All Wheel Drive | 250 km/h | 4.7 s | 9.1 l/100km | 1 acabado |
| 3.0L Gasolina | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 4.9 s | 7.8 l/100km | 1 acabado |
| 2.0L Gasolina | 258 hp | 370 Nm | Automatic | All Wheel Drive | 239 km/h | 5.7 s | 6.6 l/100km | 1 acabado |
| 2.0L Gasolina | 258 hp | 370 Nm | Automatic | Rear Wheel Drive | 239 km/h | 5.7 s | 6.1 l/100km | 1 acabado |
| 1.9L Diésel | 245 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 5.7 s | 5.4 l/100km | 1 acabado |
| 1.9L Diésel | 245 hp | 500 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.9 s | 4.8 l/100km | 1 acabado |
| 2.0L Gasolina | 211 hp | 350 Nm | Automatic | All Wheel Drive | 250 km/h | 5.4 s | 1.8 l/100km | 1 acabado |
| 2.0L Gasolina | 211 hp | 350 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.4 s | 1.6 l/100km | 3 acabados |
| 1.9L Diésel | 194 hp | 400 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.6 s | 1.4 l/100km | 6 acabados |
| 1.9L Diésel | 194 hp | 400 Nm | Automatic | All Wheel Drive | 233 km/h | 6.9 s | 4.8 l/100km | 1 acabado |
| 1.5L Gasolina | 184 hp | 280 Nm | Automatic | All Wheel Drive | 234 km/h | 8.1 s | 6.7 l/100km | 1 acabado |
| 1.5L Gasolina | 184 hp | 280 Nm | Automatic | Rear Wheel Drive | 239 km/h | 7.7 s | 6.1 l/100km | 4 acabados |
| 1.6L Diésel | 160 hp | 360 Nm | Automatic | Rear Wheel Drive | 226 km/h | 7.9 s | 4.4 l/100km | 4 acabados |
| 1.6L Diésel | 160 hp | 360 Nm | Manual | Rear Wheel Drive | 226 km/h | 8.5 s | 4.1 l/100km | 1 acabado |
| 1.5L Gasolina | 156 hp | 250 Nm | Automatic | Rear Wheel Drive | 223 km/h | 8.6 s | 6.5 l/100km | 4 acabados |
| 1.6L Gasolina | 156 hp | 250 Nm | Automatic | Rear Wheel Drive | 223 km/h | 8.5 s | 6.4 l/100km | 3 acabados |
| 1.6L Gasolina | 156 hp | 250 Nm | Manual | Rear Wheel Drive | 225 km/h | 8.2 s | 5.9 l/100km | 1 acabado |
| 1.9L Diésel | 150 hp | 360 Nm | Automatic | Rear Wheel Drive | 222 km/h | 8.1 s | 4.4 l/100km | 2 acabados |
| 1.5L Gasolina | 129 hp | 210 Nm | Automatic | Rear Wheel Drive | 208 km/h | 10.3 s | 6.5 l/100km | 3 acabados |
| 1.6L Gasolina | 129 hp | 210 Nm | Automatic | Rear Wheel Drive | 214 km/h | 9.8 s | 6.4 l/100km | 3 acabados |
| 1.6L Gasolina | 129 hp | 210 Nm | Manual | Rear Wheel Drive | 216 km/h | 9.6 s | 6.1 l/100km | 3 acabados |
| 1.6L Diésel | 122 hp | 300 Nm | Automatic | Rear Wheel Drive | 207 km/h | 9.4 s | 4.4 l/100km | 3 acabados |
| 1.6L Diésel | 122 hp | 300 Nm | Manual | Rear Wheel Drive | 207 km/h | 10.0 s | 4.4 l/100km | 3 acabados |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.