El Mercedes-Benz E-Class Facelift 1999 (1999-2002) se ofreció con 21 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 5.4L Gasolina | 354 hp | 530 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.7 s | 12.1 l/100km | 1 acabado |
| 4.3L Gasolina | 279 hp | 400 Nm | Automatic | All Wheel Drive | 250 km/h | 6.8 s | 12.3 l/100km | 4 acabados |
| 4.3L Gasolina | 279 hp | 400 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.6 s | 10.8 l/100km | 4 acabados |
| 3.2L Gasolina | 224 hp | 315 Nm | Automatic | All Wheel Drive | 230 km/h | 8.3 s | 11.1 l/100km | 5 acabados |
| 3.2L Gasolina | 224 hp | 315 Nm | Automatic | Rear Wheel Drive | 238 km/h | 7.9 s | 10.3 l/100km | 5 acabados |
| 2.8L Gasolina | 204 hp | 270 Nm | Automatic | All Wheel Drive | 223 km/h | 9.4 s | 11.2 l/100km | 5 acabados |
| 2.8L Gasolina | 204 hp | 270 Nm | Automatic | Rear Wheel Drive | 230 km/h | 9.1 s | 10.7 l/100km | 5 acabados |
| 2.8L Gasolina | 204 hp | 270 Nm | Manual | Rear Wheel Drive | 230 km/h | 8.9 s | 10.8 l/100km | 1 acabado |
| 3.2L Diésel | 197 hp | 470 Nm | Automatic | Rear Wheel Drive | 230 km/h | 8.3 s | 7.8 l/100km | 5 acabados |
| 2.7L Diésel | 170 hp | 400 Nm | Automatic | Rear Wheel Drive | 220 km/h | 9.3 s | 7.2 l/100km | 5 acabados |
| 2.7L Diésel | 170 hp | 370 Nm | Manual | Rear Wheel Drive | 225 km/h | 9.0 s | 6.9 l/100km | 1 acabado |
| 2.4L Gasolina | 170 hp | 225 Nm | Automatic | Rear Wheel Drive | 222 km/h | 10.8 s | 10.3 l/100km | 5 acabados |
| 2.4L Gasolina | 170 hp | 225 Nm | Manual | Rear Wheel Drive | 224 km/h | 9.8 s | 10.8 l/100km | 1 acabado |
| 2.0L Gasolina | 163 hp | 230 Nm | Automatic | Rear Wheel Drive | 219 km/h | 10.2 s | 9.6 l/100km | 5 acabados |
| 2.0L Gasolina | 163 hp | 230 Nm | Manual | Rear Wheel Drive | 222 km/h | 9.7 s | 8.9 l/100km | 1 acabado |
| 2.1L Diésel | 143 hp | 315 Nm | Automatic | Rear Wheel Drive | 212 km/h | 10.7 s | 6.7 l/100km | 5 acabados |
| 2.1L Diésel | 143 hp | 315 Nm | Manual | Rear Wheel Drive | 213 km/h | 10.4 s | 6.2 l/100km | 1 acabado |
| 2.0L Gasolina | 136 hp | 190 Nm | Automatic | Rear Wheel Drive | 202 km/h | 12.3 s | 9.6 l/100km | 3 acabados |
| 2.0L Gasolina | 136 hp | 190 Nm | Manual | Rear Wheel Drive | 209 km/h | 10.8 s | 9.3 l/100km | 1 acabado |
| 2.1L Diésel | 115 hp | 250 Nm | Automatic | Rear Wheel Drive | 197 km/h | 12.5 s | 6.7 l/100km | 5 acabados |
| 2.1L Diésel | 115 hp | 250 Nm | Manual | Rear Wheel Drive | 199 km/h | 12.5 s | 6.2 l/100km | 1 acabado |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.