El Mercedes-Benz E-Class Combi (2003-2006) se ofreció con 26 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 5.4L Gasolina | 476 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.7 s | 13.6 l/100km | 1 acabado |
| 5.0L Gasolina | 306 hp | 460 Nm | Automatic | All Wheel Drive | 250 km/h | 6.8 s | 12.3 l/100km | 2 acabados |
| 5.0L Gasolina | 306 hp | 460 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.5 s | 11.6 l/100km | 2 acabados |
| 3.5L Gasolina | 272 hp | 350 Nm | Automatic | All Wheel Drive | 245 km/h | 7.4 s | 10.4 l/100km | 3 acabados |
| 3.5L Gasolina | 272 hp | 350 Nm | Automatic | Rear Wheel Drive | 245 km/h | 7.1 s | 9.9 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Automatic | All Wheel Drive | 232 km/h | 8.3 s | 10.3 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Automatic | Rear Wheel Drive | 238 km/h | 7.9 s | 9.7 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Manual | Rear Wheel Drive | 246 km/h | 8.1 s | 9.6 l/100km | 3 acabados |
| 3.0L Diésel | 224 hp | 510 Nm | Automatic | All Wheel Drive | 236 km/h | 8.1 s | 8.3 l/100km | 3 acabados |
| 3.0L Diésel | 224 hp | 510 Nm | Automatic | Rear Wheel Drive | 240 km/h | 7.3 s | 7.6 l/100km | 3 acabados |
| 3.2L Gasolina | 224 hp | 315 Nm | Automatic | All Wheel Drive | 233 km/h | 9.0 s | 10.6 l/100km | 3 acabados |
| 3.2L Gasolina | 224 hp | 315 Nm | Automatic | Rear Wheel Drive | 233 km/h | 8.5 s | 10.6 l/100km | 3 acabados |
| 3.2L Diésel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 234 km/h | 8.2 s | 7.3 l/100km | 3 acabados |
| 3.0L Diésel | 190 hp | 440 Nm | Automatic | All Wheel Drive | 226 km/h | 9.0 s | 8.2 l/100km | 3 acabados |
| 3.0L Diésel | 190 hp | 440 Nm | Automatic | Rear Wheel Drive | 230 km/h | 8.2 s | 7.2 l/100km | 3 acabados |
| 3.0L Diésel | 190 hp | 400 Nm | Manual | Rear Wheel Drive | 231 km/h | 9.1 s | 7.6 l/100km | 3 acabados |
| 3.2L Diésel | 177 hp | 425 Nm | Automatic | Rear Wheel Drive | 220 km/h | 9.3 s | 7.6 l/100km | 3 acabados |
| 2.7L Diésel | 177 hp | 400 Nm | Automatic | Rear Wheel Drive | 220 km/h | 9.3 s | 7.2 l/100km | 3 acabados |
| 2.7L Diésel | 177 hp | 400 Nm | Manual | Rear Wheel Drive | 223 km/h | 9.3 s | 7.1 l/100km | 3 acabados |
| 2.6L Gasolina | 177 hp | 240 Nm | Automatic | All Wheel Drive | 214 km/h | 10.8 s | 10.9 l/100km | 3 acabados |
| 2.6L Gasolina | 177 hp | 240 Nm | Automatic | Rear Wheel Drive | 220 km/h | 10.1 s | 10.9 l/100km | 3 acabados |
| 2.6L Gasolina | 177 hp | 240 Nm | Manual | Rear Wheel Drive | 223 km/h | 9.4 s | 11.4 l/100km | 3 acabados |
| 1.8L Gasolina | 163 hp | 240 Nm | Automatic | Rear Wheel Drive | 218 km/h | 10.6 s | 9.2 l/100km | 3 acabados |
| 1.8L Gasolina | 163 hp | 240 Nm | Manual | Rear Wheel Drive | 220 km/h | 10.1 s | 9.1 l/100km | 3 acabados |
| 2.1L Diésel | 150 hp | 340 Nm | Automatic | Rear Wheel Drive | 207 km/h | 11.1 s | 7.1 l/100km | 6 acabados |
| 2.1L Diésel | 150 hp | 340 Nm | Manual | Rear Wheel Drive | 208 km/h | 10.6 s | 6.9 l/100km | 6 acabados |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.