El Mercedes-Benz E-Class Combi Facelift 2006 (2006-2009) se ofreció con 22 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 6.2L Gasolina | 514 hp | 630 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.6 s | 14.5 l/100km | 1 acabado |
| 5.5L Gasolina | 388 hp | 530 Nm | Automatic | All Wheel Drive | 250 km/h | 5.7 s | 12.3 l/100km | 2 acabados |
| 5.5L Gasolina | 388 hp | 530 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.4 s | 11.8 l/100km | 2 acabados |
| 3.5L Gasolina | 292 hp | 365 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.0 s | 8.9 l/100km | 2 acabados |
| 3.5L Gasolina | 272 hp | 350 Nm | Automatic | All Wheel Drive | 245 km/h | 7.4 s | 10.6 l/100km | 3 acabados |
| 3.5L Gasolina | 272 hp | 350 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.1 s | 9.9 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Automatic | All Wheel Drive | 232 km/h | 8.3 s | 10.3 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Automatic | Rear Wheel Drive | 238 km/h | 7.9 s | 9.7 l/100km | 3 acabados |
| 3.0L Gasolina | 231 hp | 300 Nm | Manual | Rear Wheel Drive | 246 km/h | 8.1 s | 9.6 l/100km | 3 acabados |
| 3.0L Diésel | 224 hp | 540 Nm | Automatic | All Wheel Drive | 236 km/h | 8.1 s | 8.3 l/100km | 3 acabados |
| 3.0L Diésel | 224 hp | 540 Nm | Automatic | Rear Wheel Drive | 240 km/h | 7.3 s | 7.6 l/100km | 3 acabados |
| 2.5L Gasolina | 204 hp | 245 Nm | Automatic | Rear Wheel Drive | 228 km/h | 9.9 s | 9.6 l/100km | 3 acabados |
| 2.5L Gasolina | 204 hp | 245 Nm | Manual | Rear Wheel Drive | 233 km/h | 9.9 s | 9.6 l/100km | 3 acabados |
| 3.0L Diésel | 190 hp | 440 Nm | Automatic | All Wheel Drive | 226 km/h | 9.0 s | 8.2 l/100km | 3 acabados |
| 3.0L Diésel | 190 hp | 440 Nm | Automatic | Rear Wheel Drive | 230 km/h | 8.2 s | 7.6 l/100km | 3 acabados |
| 3.0L Diésel | 190 hp | 400 Nm | Manual | Rear Wheel Drive | 231 km/h | 9.1 s | 7.2 l/100km | 3 acabados |
| 1.8L Gasolina | 184 hp | 250 Nm | Automatic | Rear Wheel Drive | 222 km/h | 9.7 s | 9.2 l/100km | 3 acabados |
| 1.8L Gasolina | 184 hp | 250 Nm | Manual | Rear Wheel Drive | 225 km/h | 9.5 s | 8.9 l/100km | 3 acabados |
| 2.1L Diésel | 170 hp | 400 Nm | Automatic | Rear Wheel Drive | 218 km/h | 9.1 s | 7.3 l/100km | 3 acabados |
| 2.1L Diésel | 170 hp | 400 Nm | Manual | Rear Wheel Drive | 218 km/h | 9.1 s | 7.1 l/100km | 3 acabados |
| 2.1L Diésel | 136 hp | 340 Nm | Automatic | Rear Wheel Drive | 200 km/h | 10.7 s | 7.1 l/100km | 3 acabados |
| 2.1L Diésel | 136 hp | 340 Nm | Manual | Rear Wheel Drive | 202 km/h | 10.5 s | 7.1 l/100km | 3 acabados |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.
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