El Mercedes-Benz E-Class Facelift 2013 (2013-2016) se ofreció con 28 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 5.5L Gasolina | 585 hp | 800 Nm | Automatic | All Wheel Drive | 250 km/h | 3.6 s | 10.3 l/100km | 1 acabado |
| 5.5L Gasolina | 558 hp | 720 Nm | Automatic | All Wheel Drive | 250 km/h | 3.7 s | 10.3 l/100km | 1 acabado |
| 5.5L Gasolina | 558 hp | 720 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.2 s | 9.8 l/100km | 1 acabado |
| 4.7L Gasolina | 408 hp | 600 Nm | Automatic | All Wheel Drive | 250 km/h | 4.8 s | 9.4 l/100km | 3 acabados |
| 4.7L Gasolina | 408 hp | 600 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.9 s | 8.9 l/100km | 3 acabados |
| 3.5L Gasolina | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 5.3 s | 7.4 l/100km | 3 acabados |
| 3.5L Gasolina | 333 hp | 480 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.3 s | 6.9 l/100km | 3 acabados |
| 3.0L Gasolina | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 5.3 s | 8.1 l/100km | 3 acabados |
| 3.0L Gasolina | 333 hp | 480 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.3 s | 7.5 l/100km | 3 acabados |
| 3.5L Gasolina | 306 hp | 370 Nm | Automatic | All Wheel Drive | 250 km/h | 6.6 s | 7.4 l/100km | 3 acabados |
| 3.5L Gasolina | 306 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.3 s | 6.8 l/100km | 3 acabados |
| 3.0L Diésel | 258 hp | 620 Nm | Automatic | All Wheel Drive | 250 km/h | 6.6 s | 5.7 l/100km | 3 acabados |
| 3.0L Diésel | 258 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.4 s | 5.0 l/100km | 3 acabados |
| 3.0L Diésel | 252 hp | 620 Nm | Automatic | All Wheel Drive | 245 km/h | 6.7 s | 6.0 l/100km | 3 acabados |
| 3.0L Diésel | 252 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.6 s | 5.3 l/100km | 6 acabados |
| 3.5L Gasolina | 252 hp | 340 Nm | Automatic | All Wheel Drive | 245 km/h | 7.4 s | 7.4 l/100km | 3 acabados |
| 3.5L Gasolina | 252 hp | 340 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.1 s | 6.8 l/100km | 3 acabados |
| 3.0L Diésel | 231 hp | 540 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.1 s | 5.0 l/100km | 6 acabados |
| 2.0L Gasolina | 211 hp | 350 Nm | Automatic | Rear Wheel Drive | 243 km/h | 7.4 s | 5.8 l/100km | 3 acabados |
| 2.1L Diésel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 242 km/h | 7.5 s | 3.8 l/100km | 16 acabados |
| 2.1L Diésel | 204 hp | 500 Nm | Automatic | All Wheel Drive | 238 km/h | 7.8 s | 4.4 l/100km | 6 acabados |
| 2.1L Diésel | 204 hp | 500 Nm | Manual | Rear Wheel Drive | 240 km/h | 7.5 s | 4.6 l/100km | 6 acabados |
| 2.0L Gasolina | 184 hp | 270 Nm | Automatic | Rear Wheel Drive | 233 km/h | 7.9 s | 5.8 l/100km | 8 acabados |
| 2.0L Gasolina | 184 hp | 270 Nm | Manual | Rear Wheel Drive | 233 km/h | 8.2 s | 6.1 l/100km | 3 acabados |
| 2.1L Diésel | 170 hp | 400 Nm | Automatic | Rear Wheel Drive | 227 km/h | 8.7 s | 4.5 l/100km | 11 acabados |
| 2.1L Diésel | 170 hp | 400 Nm | Manual | Rear Wheel Drive | 228 km/h | 8.6 s | 4.5 l/100km | 6 acabados |
| 2.1L Diésel | 136 hp | 360 Nm | Automatic | Rear Wheel Drive | 207 km/h | 9.5 s | 4.6 l/100km | 6 acabados |
| 2.1L Diésel | 136 hp | 360 Nm | Manual | Rear Wheel Drive | 210 km/h | 10.2 s | 4.6 l/100km | 6 acabados |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.