El Mercedes-Benz E-Class Estate W212 (2009-2013) se ofreció con 27 configuraciones de motor distintas en toda su gama.
| Motor | Potencia | Par motor | Transmisión | Ruedas motrices | Velocidad máxima | 0-100 km/h | Consumo | Disponible en |
|---|---|---|---|---|---|---|---|---|
| 5.5L Gasolina | 525 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.4 s | 10.0 l/100km | 1 acabado |
| 6.2L Gasolina | 525 hp | 630 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.6 s | 12.8 l/100km | 1 acabado |
| 4.7L Gasolina | 408 hp | 600 Nm | Automatic | All Wheel Drive | 250 km/h | 5.4 s | 9.5 l/100km | 2 acabados |
| 4.7L Gasolina | 408 hp | 600 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.4 s | 9.3 l/100km | 2 acabados |
| 5.5L Gasolina | 388 hp | 530 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.4 s | 11.1 l/100km | 2 acabados |
| 3.5L Gasolina | 306 hp | 370 Nm | Automatic | All Wheel Drive | 243 km/h | 7.8 s | 7.8 l/100km | 3 acabados |
| 3.5L Gasolina | 306 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.7 s | 7.1 l/100km | 3 acabados |
| 3.5L Gasolina | 292 hp | 365 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.0 s | 8.6 l/100km | 3 acabados |
| 3.5L Gasolina | 272 hp | 350 Nm | Automatic | All Wheel Drive | 243 km/h | 7.5 s | 10.2 l/100km | 3 acabados |
| 3.0L Diésel | 265 hp | 620 Nm | Automatic | All Wheel Drive | 247 km/h | 7.3 s | 7.1 l/100km | 3 acabados |
| 3.0L Diésel | 265 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.7 s | 6.4 l/100km | 3 acabados |
| 3.5L Gasolina | 252 hp | 340 Nm | Automatic | All Wheel Drive | 243 km/h | 7.8 s | 7.8 l/100km | 3 acabados |
| 3.5L Gasolina | 252 hp | 340 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.5 s | 7.1 l/100km | 3 acabados |
| 3.0L Diésel | 231 hp | 540 Nm | Automatic | All Wheel Drive | 235 km/h | 7.5 s | 7.6 l/100km | 3 acabados |
| 3.0L Diésel | 231 hp | 540 Nm | Automatic | Rear Wheel Drive | 240 km/h | 7.2 s | 7.0 l/100km | 6 acabados |
| 3.0L Diésel | 211 hp | 540 Nm | Automatic | Rear Wheel Drive | 232 km/h | 8.0 s | 7.2 l/100km | 3 acabados |
| 3.0L Diésel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 230 km/h | 8.3 s | 7.0 l/100km | 3 acabados |
| 2.1L Diésel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 232 km/h | 7.8 s | 4.4 l/100km | 9 acabados |
| 2.1L Diésel | 204 hp | 500 Nm | Automatic | All Wheel Drive | 216 km/h | 8.6 s | — | 3 acabados |
| 2.1L Diésel | 204 hp | 500 Nm | Manual | Rear Wheel Drive | 232 km/h | 7.8 s | 5.2 l/100km | 3 acabados |
| 1.8L Gasolina | 204 hp | 310 Nm | Automatic | Rear Wheel Drive | 230 km/h | 8.1 s | 6.8 l/100km | 6 acabados |
| 1.8L Gasolina | 184 hp | 270 Nm | Automatic | Rear Wheel Drive | 224 km/h | 8.5 s | 6.8 l/100km | 7 acabados |
| 1.8L Gasolina | 184 hp | 270 Nm | Manual | Rear Wheel Drive | 225 km/h | 8.7 s | 7.5 l/100km | 6 acabados |
| 2.1L Diésel | 170 hp | 400 Nm | Automatic | Rear Wheel Drive | 216 km/h | 9.0 s | 5.3 l/100km | 6 acabados |
| 2.1L Diésel | 170 hp | 400 Nm | Manual | Rear Wheel Drive | 218 km/h | 8.8 s | 5.2 l/100km | 3 acabados |
| 2.1L Diésel | 136 hp | 360 Nm | Automatic | Rear Wheel Drive | 203 km/h | 10.1 s | 5.3 l/100km | 7 acabados |
| 2.1L Diésel | 136 hp | 360 Nm | Manual | Rear Wheel Drive | 205 km/h | 10.9 s | 5.3 l/100km | 3 acabados |
Cada fila es una configuración mecánica distinta — cilindrada, potencia, transmisión, tracción y tipo de combustible — deduplicada entre acabados que comparten el mismo motor. Las diferencias solo de acabado (interior, llantas, opciones) no crean una fila aparte.