Mercedes-Benz E-Class (2013–2016) nudio se s 28 različitih konfiguracija motora kroz cijelu ponudu opreme.
| Motor | Snaga | Okretni moment | Mjenjač | Pogon | Najveća brzina | 0-100 km/h | Potrošnja | Dostupno u |
|---|---|---|---|---|---|---|---|---|
| 5.5L Benzin | 585 hp | 800 Nm | Automatic | All Wheel Drive | 250 km/h | 3.6 s | 10.3 l/100km | 1 verziji |
| 5.5L Benzin | 558 hp | 720 Nm | Automatic | All Wheel Drive | 250 km/h | 3.7 s | 10.3 l/100km | 1 verziji |
| 5.5L Benzin | 558 hp | 720 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.2 s | 9.8 l/100km | 1 verziji |
| 4.7L Benzin | 408 hp | 600 Nm | Automatic | All Wheel Drive | 250 km/h | 4.8 s | 9.4 l/100km | 3 verzije |
| 4.7L Benzin | 408 hp | 600 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.9 s | 8.9 l/100km | 3 verzije |
| 3.5L Benzin | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 5.3 s | 7.4 l/100km | 3 verzije |
| 3.5L Benzin | 333 hp | 480 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.3 s | 6.9 l/100km | 3 verzije |
| 3.0L Benzin | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 5.3 s | 8.1 l/100km | 3 verzije |
| 3.0L Benzin | 333 hp | 480 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.3 s | 7.5 l/100km | 3 verzije |
| 3.5L Benzin | 306 hp | 370 Nm | Automatic | All Wheel Drive | 250 km/h | 6.6 s | 7.4 l/100km | 3 verzije |
| 3.5L Benzin | 306 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.3 s | 6.8 l/100km | 3 verzije |
| 3.0L Dizel | 258 hp | 620 Nm | Automatic | All Wheel Drive | 250 km/h | 6.6 s | 5.7 l/100km | 3 verzije |
| 3.0L Dizel | 258 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.4 s | 5.0 l/100km | 3 verzije |
| 3.0L Dizel | 252 hp | 620 Nm | Automatic | All Wheel Drive | 245 km/h | 6.7 s | 6.0 l/100km | 3 verzije |
| 3.0L Dizel | 252 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.6 s | 5.3 l/100km | 6 verzija |
| 3.5L Benzin | 252 hp | 340 Nm | Automatic | All Wheel Drive | 245 km/h | 7.4 s | 7.4 l/100km | 3 verzije |
| 3.5L Benzin | 252 hp | 340 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.1 s | 6.8 l/100km | 3 verzije |
| 3.0L Dizel | 231 hp | 540 Nm | Automatic | Rear Wheel Drive | 250 km/h | 7.1 s | 5.0 l/100km | 6 verzija |
| 2.0L Benzin | 211 hp | 350 Nm | Automatic | Rear Wheel Drive | 243 km/h | 7.4 s | 5.8 l/100km | 3 verzije |
| 2.1L Dizel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 242 km/h | 7.5 s | 3.8 l/100km | 16 verzija |
| 2.1L Dizel | 204 hp | 500 Nm | Automatic | All Wheel Drive | 238 km/h | 7.8 s | 4.4 l/100km | 6 verzija |
| 2.1L Dizel | 204 hp | 500 Nm | Manual | Rear Wheel Drive | 240 km/h | 7.5 s | 4.6 l/100km | 6 verzija |
| 2.0L Benzin | 184 hp | 270 Nm | Automatic | Rear Wheel Drive | 233 km/h | 7.9 s | 5.8 l/100km | 8 verzija |
| 2.0L Benzin | 184 hp | 270 Nm | Manual | Rear Wheel Drive | 233 km/h | 8.2 s | 6.1 l/100km | 3 verzije |
| 2.1L Dizel | 170 hp | 400 Nm | Automatic | Rear Wheel Drive | 227 km/h | 8.7 s | 4.5 l/100km | 11 verzija |
| 2.1L Dizel | 170 hp | 400 Nm | Manual | Rear Wheel Drive | 228 km/h | 8.6 s | 4.5 l/100km | 6 verzija |
| 2.1L Dizel | 136 hp | 360 Nm | Automatic | Rear Wheel Drive | 207 km/h | 9.5 s | 4.6 l/100km | 6 verzija |
| 2.1L Dizel | 136 hp | 360 Nm | Manual | Rear Wheel Drive | 210 km/h | 10.2 s | 4.6 l/100km | 6 verzija |
Svaki je red zasebna mehanička konfiguracija — obujam motora, snaga, mjenjač, pogon i vrsta goriva — deduplicirana kroz razine opreme koje dijele isti motor. Razlike samo u opremi (unutrašnjost, naplatci, opcije) ne stvaraju zaseban red.