Mercedes-Benz E-Class (2020–2022) nudio se s 15 različitih konfiguracija motora kroz cijelu ponudu opreme.
| Motor | Snaga | Okretni moment | Mjenjač | Pogon | Najveća brzina | 0-100 km/h | Potrošnja | Dostupno u |
|---|---|---|---|---|---|---|---|---|
| 4.0L Benzin | 612 hp | 850 Nm | Automatic | All Wheel Drive | 250 km/h | 3.4 s | 12.1 l/100km | 1 verziji |
| 4.0L Benzin | 571 hp | 750 Nm | Automatic | All Wheel Drive | 250 km/h | 3.5 s | 12.0 l/100km | 1 verziji |
| 3.0L Benzin | 435 hp | 520 Nm | Automatic | All Wheel Drive | 250 km/h | 4.5 s | 9.1 l/100km | 1 verziji |
| 3.0L Benzin | 367 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 5.0 s | 8.2 l/100km | 3 verzije |
| 2.9L Dizel | 330 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 4.9 s | 6.6 l/100km | 3 verzije |
| 2.0L Dizel | 265 hp | 550 Nm | Automatic | All Wheel Drive | 250 km/h | 6.3 s | 5.8 l/100km | 1 verziji |
| 2.0L Benzin | 258 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.2 s | 7.3 l/100km | 1 verziji |
| 2.0L Benzin | 211 hp | 350 Nm | Automatic | All Wheel Drive | 250 km/h | 5.7 s | 1.7 l/100km | 3 verzije |
| 2.0L Benzin | 211 hp | 350 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.7 s | 1.6 l/100km | 5 verzija |
| 2.0L Dizel | 200 hp | 440 Nm | Automatic | Rear Wheel Drive | 238 km/h | 7.4 s | 4.8 l/100km | 2 verzije |
| 2.0L Benzin | 197 hp | 320 Nm | Automatic | All Wheel Drive | 232 km/h | 7.6 s | 7.7 l/100km | 1 verziji |
| 2.0L Benzin | 197 hp | 320 Nm | Automatic | Rear Wheel Drive | 240 km/h | 7.5 s | 7.2 l/100km | 6 verzija |
| 1.9L Dizel | 194 hp | 400 Nm | Automatic | All Wheel Drive | 235 km/h | 5.9 s | 1.7 l/100km | 4 verzije |
| 1.9L Dizel | 194 hp | 400 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.9 s | 1.2 l/100km | 6 verzija |
| 1.6L Dizel | 160 hp | 360 Nm | Automatic | Rear Wheel Drive | 226 km/h | 8.4 s | 4.9 l/100km | 6 verzija |
Svaki je red zasebna mehanička konfiguracija — obujam motora, snaga, mjenjač, pogon i vrsta goriva — deduplicirana kroz razine opreme koje dijele isti motor. Razlike samo u opremi (unutrašnjost, naplatci, opcije) ne stvaraju zaseban red.