Mercedes-Benz S-Class Facelift 2017 (2017-2020) nuđen je sa 12 različitih konfiguracija motora kroz celu ponudu opreme.
| Motor | Snaga | Obrtni moment | Menjač | Pogon | Najveća brzina | 0-100 km/h | Potrošnja | Dostupno u |
|---|---|---|---|---|---|---|---|---|
| 6.0L Benzin | 630 hp | 1.000 Nm | Automatic | All Wheel Drive | 250 km/h | 4.3 s | 14.2 l/100km | 2 verzije |
| 4.0L Benzin | 612 hp | 900 Nm | Automatic | All Wheel Drive | 250 km/h | 3.5 s | 11.2 l/100km | 1 verziji |
| 6.0L Benzin | 530 hp | 830 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.6 s | 14.0 l/100km | 1 verziji |
| 4.0L Benzin | 469 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 4.9 s | 10.3 l/100km | 4 verzije |
| 4.0L Benzin | 469 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.9 s | 10.1 l/100km | 2 verzije |
| 3.0L Benzin | 367 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 5.0 s | 2.8 l/100km | 1 verziji |
| 3.0L Benzin | 367 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 4.9 s | 8.1 l/100km | 2 verzije |
| 3.0L Benzin | 367 hp | 500 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.1 s | 7.3 l/100km | 2 verzije |
| 2.9L Dizel | 340 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 5.2 s | 6.2 l/100km | 2 verzije |
| 2.9L Dizel | 340 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.4 s | 5.9 l/100km | 2 verzije |
| 2.9L Dizel | 286 hp | 600 Nm | Automatic | All Wheel Drive | 250 km/h | 5.8 s | 6.2 l/100km | 2 verzije |
| 2.9L Dizel | 286 hp | 600 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.0 s | 5.9 l/100km | 2 verzije |
Svaki red je zasebna mehanička konfiguracija — zapremina motora, snaga, menjač, pogon i vrsta goriva — deduplikovana kroz nivoe opreme koji dele isti motor. Razlike samo u opremi (enterijer, felne, opcije) ne stvaraju poseban red.