Mercedes-Benz S-Class W222 (2013-2017) nuđen je sa 12 različitih konfiguracija motora kroz celu ponudu opreme.
| Motor | Snaga | Obrtni moment | Menjač | Pogon | Najveća brzina | 0-100 km/h | Potrošnja | Dostupno u |
|---|---|---|---|---|---|---|---|---|
| 6.0L Benzin | 630 hp | 1.000 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.3 s | 11.9 l/100km | 1 verziji |
| 5.5L Benzin | 585 hp | 900 Nm | Automatic | All Wheel Drive | 250 km/h | 4.0 s | 10.3 l/100km | 1 verziji |
| 5.5L Benzin | 585 hp | 900 Nm | Automatic | Rear Wheel Drive | 250 km/h | 4.4 s | 10.1 l/100km | 1 verziji |
| 6.0L Benzin | 530 hp | 830 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.0 s | 11.7 l/100km | 2 verzije |
| 4.7L Benzin | 456 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 5.0 s | 9.4 l/100km | 13 verzija |
| 4.7L Benzin | 456 hp | 700 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.0 s | 8.9 l/100km | 13 verzija |
| 3.0L Benzin | 333 hp | 480 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.2 s | 2.8 l/100km | 3 verzije |
| 3.0L Benzin | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 6.1 s | 8.4 l/100km | 6 verzija |
| 3.5L Benzin | 306 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.8 s | 6.0 l/100km | 6 verzija |
| 3.0L Dizel | 258 hp | 620 Nm | Automatic | All Wheel Drive | 250 km/h | 6.8 s | 5.7 l/100km | 12 verzija |
| 3.0L Dizel | 258 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.5 s | 5.4 l/100km | 12 verzija |
| 2.1L Dizel | 204 hp | 500 Nm | Automatic | Rear Wheel Drive | 240 km/h | 7.6 s | 4.3 l/100km | 12 verzija |
Svaki red je zasebna mehanička konfiguracija — zapremina motora, snaga, menjač, pogon i vrsta goriva — deduplikovana kroz nivoe opreme koji dele isti motor. Razlike samo u opremi (enterijer, felne, opcije) ne stvaraju poseban red.