Mercedes-Benz E-Class Estate (2016–2020) sa ponúkal s 21 rôznymi konfiguráciami motora naprieč výbavami.
| Motor | Výkon | Krútiaci moment | Prevodovka | Pohon | Najvyššia rýchlosť | 0-100 km/h | Spotreba | Dostupné pri |
|---|---|---|---|---|---|---|---|---|
| 4.0L Benzín | 612 hp | 850 Nm | Automatic | All Wheel Drive | 250 km/h | 3.6 s | 10.8 l/100km | 1 výbave |
| 4.0L Benzín | 571 hp | 750 Nm | Automatic | All Wheel Drive | 250 km/h | 3.6 s | 10.8 l/100km | 1 výbave |
| 3.0L Benzín | 435 hp | 520 Nm | Automatic | All Wheel Drive | 250 km/h | 4.5 s | 8.7 l/100km | 1 výbave |
| 3.0L Benzín | 401 hp | 520 Nm | Automatic | All Wheel Drive | 250 km/h | 4.7 s | 8.6 l/100km | 1 výbave |
| 3.0L Benzín | 367 hp | 500 Nm | Automatic | All Wheel Drive | 250 km/h | 5.8 s | 8.7 l/100km | 1 výbave |
| 2.9L Diesel | 340 hp | 700 Nm | Automatic | All Wheel Drive | 250 km/h | 5.1 s | 6.0 l/100km | 1 výbave |
| 3.5L Benzín | 333 hp | 480 Nm | Automatic | All Wheel Drive | 250 km/h | 5.4 s | 7.9 l/100km | 1 výbave |
| 2.9L Diesel | 286 hp | 600 Nm | Automatic | Rear Wheel Drive | 250 km/h | 5.7 s | 5.5 l/100km | 1 výbave |
| 3.0L Diesel | 258 hp | 620 Nm | Automatic | All Wheel Drive | 250 km/h | 6.2 s | 6.3 l/100km | 1 výbave |
| 3.0L Diesel | 258 hp | 620 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.0 s | 5.7 l/100km | 1 výbave |
| 2.0L Benzín | 258 hp | 370 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.3 s | 6.7 l/100km | 1 výbave |
| 1.9L Diesel | 245 hp | 500 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.5 s | 5.2 l/100km | 1 výbave |
| 2.0L Benzín | 211 hp | 350 Nm | Automatic | Rear Wheel Drive | 243 km/h | 7.2 s | 6.2 l/100km | 1 výbave |
| 2.0L Benzín | 197 hp | 320 Nm | Automatic | All Wheel Drive | 225 km/h | 7.9 s | 7.0 l/100km | 1 výbave |
| 2.0L Benzín | 197 hp | 320 Nm | Automatic | Rear Wheel Drive | 231 km/h | 7.8 s | 6.6 l/100km | 3 výbavách |
| 1.9L Diesel | 194 hp | 400 Nm | Automatic | Rear Wheel Drive | 250 km/h | 6.0 s | 1.7 l/100km | 7 výbavách |
| 1.9L Diesel | 194 hp | 400 Nm | Automatic | All Wheel Drive | 233 km/h | 7.8 s | 5.2 l/100km | 1 výbave |
| 2.0L Benzín | 184 hp | 300 Nm | Automatic | All Wheel Drive | 228 km/h | 8.3 s | 7.6 l/100km | 1 výbave |
| 2.0L Benzín | 184 hp | 300 Nm | Automatic | Rear Wheel Drive | 231 km/h | 8.1 s | 7.1 l/100km | 3 výbavách |
| 1.6L Diesel | 160 hp | 360 Nm | Automatic | Rear Wheel Drive | 220 km/h | 8.9 s | 4.6 l/100km | 1 výbave |
| 1.9L Diesel | 150 hp | 360 Nm | Automatic | Rear Wheel Drive | 217 km/h | 8.7 s | 4.9 l/100km | 4 výbavách |
Každý riadok je samostatná mechanická konfigurácia — objem motora, výkon, prevodovka, pohon a typ paliva — deduplikovaná naprieč výbavami, ktoré zdieľajú rovnaký motor. Rozdiely len vo výbave (interiér, kolesá, príplatky) samostatný riadok nevytvárajú.